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Can some blood pressure medications cause an increase in triglyceride levels?
- Don / North Carolina
Mayo Clinic hypertension specialist Sheldon Sheps, M.D., and colleagues answer select questions from readers.
Answer
ישנן תרופות מסויימות להורדת לחץ הדם שיכולות להשפיע על רמות הכולסטרול, כולל על רמות הטריגליצרידים.
חוסמי-ביתא - בעיקר התרופות הישנות יותר כמו פרופראנולול, אטנולול ומטופרולול - עלולות להעלות מעט את רמות הטריגליצרידים ולהוריד את רמות הליפופרוטאין בצפיפות גבוהה (HDL, או הכולסטרול "הטוב"). בדרך כלל מצב זה בולט באנשים בעלי נטייה לתסמונת מטבולית או כאלו שכבר סובלים ממנה. תסמונת מטבולית היא קבוצת מצבים הכוללים לחץ דם גבוה, רמות סוכר גבוהות בדם, עודף שומן סביב הבטן ורמות כולסטרול גבוהות. חוסמי ביתא חדשות יותר כמו קארבדילול ו
Beta blockers — most notably the older ones such as — a cluster of conditions that includes high blood pressure, high blood sugar, excess fat around the abdomen and high cholesterol. Newer beta blockers such as carvedilol and nebivolol are less often associated with these changes.
Thiazide diuretics in higher doses also can slightly increase triglycerides as well as total cholesterol. Some observational studies have linked such changes with an increase in cardiovascular events, such as heart attacks. However, controlled trials haven't corroborated this, and in fact, have found a reduction in cardiovascular events with diuretics. Still, meta-analyses of the older beta blocker drugs conclude that these agents should not be initial drugs of choice in the treatment of high blood pressure except in specific instances such as to prevent recurrent coronary artery disease, to manage heart failure and to treat certain arrhythmias.
Before making any changes in your drug therapy, discuss this with your doctor.
RELATED
High blood pressure medication: When should I take it?
Calcium supplements: Do they interfere with blood pressure drugs?
Choosing blood pressure medications
Diuretics
Angiotensin II receptor blockers
Alpha blockers
Central-acting agents
Vasodilators
Beta blockers
Angiotensin-converting enzyme (ACE) inhibitors
Calcium channel blockers
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Mar 8, 2008
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