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Irregularities in pain-related nerve endings in insulin-producing pancreatic cells may play a role in the development of type 1 diabetes, says a Canadian study in this week's issue of Cell.

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The finding could lead to new ways of treating and even preventing the disease, said the researchers at Toronto's Hospital for Sick Children and the University of Calgary.

Most type 1 diabetes research has looked at the immune system as the major cause of the disease. But this study of mice that are prone to diabetes identified a control circuit between insulin-producing pancreatic cells and their associated pain nerves, the Canadian Press reported.

Removing these nerve cells prevented the destruction of cells that produce insulin. Most of the mice did not develop diabetes after these nerve cells were removed, the study said.

The researchers plan to conduct studies of people with a family history of diabetes in order to determine if they have abnormal pain sensitivity that may be associated with the onset of diabetes, the CP reported. - (HealthDayNews)

Read more:
Diabetes Centre
Pain Centre
December 2006
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